NAD+

Description

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every living cell. It is involved in hundreds of metabolic processes, acting as the primary electron transporter in the Krebs cycle to facilitate the conversion of nutrients into Adenosine Triphosphate (ATP)—the cellular fuel source.

While NAD+ is naturally occurring, levels decline precipitously with biological age. Research has identified NAD+ as the essential substrate for Sirtuins (a family of proteins regulating cellular health and aging) and PARPs (enzymes responsible for DNA repair). Consequently, exogenous NAD+ administration is the subject of intense investigation for its potential to restore mitochondrial efficiency, repair genomic instability, and modulate the circadian rhythm.

Key Research Applications

• Sirtuin Activation (Longevity): NAD+ is the fuel for Sirtuins (specifically SIRT1), often referred to as “longevity genes.” Research suggests that maintaining high intracellular NAD+ levels is required for Sirtuins to perform their role in gene silencing and extending replicative lifespan in cell models.

• Mitochondrial Biogenesis: Investigated for its ability to restore mitochondrial function in aged tissue. Studies in murine models indicate that NAD+ repletion can improve mitochondrial electron transport chain activity, effectively reversing “pseudohypoxia” (a state of low oxygen utilization) common in aging cells.

• Neuroprotection & DNA Repair: Because it powers PARP enzymes (which fix damaged DNA strands), NAD+ is heavily researched for its neuroprotective properties and its role in protecting cells from oxidative stress and ischemic damage.

⚠️ FOR RESEARCH PURPOSES ONLY This product is intended for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic use. Handle with care and adhere to all laboratory safety protocols.