MOTS-c

Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide of 16 amino acids that represents a paradigm shift in peptide research. Unlike most peptides which are encoded by the nuclear genome, MOTS-c is encoded within the DNA of the mitochondria itself.

It belongs to a class of peptides known as “mitochondrial-derived peptides” (MDPs). Research indicates that MOTS-c acts as a signaling molecule that translocates to the nucleus to regulate gene expression in response to metabolic stress. It is widely categorized in literature as an “exercise mimetic” because its administration in animal models has been observed to replicate the physiologic metabolic benefits of exercise—specifically the activation of the AMPK pathway—without physical exertion.

Key Research Applications

• Metabolic Homeostasis & AMPK: MOTS-c is investigated primarily for its ability to target the Folate-Methionine cycle, leading to the activation of AMPK (Adenosine Monophosphate-Activated Protein Kinase). This pathway acts as a master switch for cellular energy, promoting glucose uptake and fatty acid oxidation.

• “Exercise Mimetic” Properties: Studies in mice have shown that MOTS-c administration can prevent high-fat diet-induced obesity and age-dependent insulin resistance, effects traditionally associated with consistent endurance training.

• Mitochondrial Biogenesis: As a mitochondrial-derived signal, it is researched for its potential to enhance mitochondrial function and density, which naturally decline with age.

⚠️ FOR RESEARCH PURPOSES ONLY This product is intended for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic use. Handle with care and adhere to all laboratory safety protocols.