5-amino-1mq

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule drug that has emerged as a breakthrough agent in the study of metabolic efficiency. Unlike peptides which often mimic hormones, 5-Amino-1MQ acts as a specific inhibitor of an enzyme called NNMT (Nicotinamide N-methyltransferase).

NNMT is a cytosolic enzyme that regulates energy balance in adipose tissue. High levels of NNMT have been linked to obesity, insulin resistance, and a slowdown in metabolic rate. By inhibiting this enzyme, 5-Amino-1MQ is investigated for its ability to “brake” the accumulation of white adipose tissue and correct metabolic dysfunction at the cellular level.

Key Research Applications

• Obesity & Fat Metabolism: Research in diet-induced obese mice has demonstrated that 5-Amino-1MQ administration can significantly reduce body mass and white adipose tissue mass without any change in food intake. It works by shifting the metabolic profile of fat cells, essentially making the metabolism less efficient at storing energy as fat.

• NAD+ Restoration (Anti-Aging): NNMT works by methylating nicotinamide, which removes it from the “NAD+ salvage pathway.” By blocking NNMT, 5-Amino-1MQ preserves nicotinamide, allowing the cell to recycle it back into NAD+ (Nicotinamide Adenine Dinucleotide). Higher NAD+ levels are critical for mitochondrial health, DNA repair, and longevity research.

• Muscle Satellite Cells: Unlike many weight-loss agents (such as GLP-1 agonists) which can cause muscle atrophy, 5-Amino-1MQ is researched for its potential to enhance muscle function. Studies suggest it may activate satellite cells in muscle tissue, potentially improving contractile force and muscle density even during a caloric deficit.

⚠️ FOR RESEARCH PURPOSES ONLY This product is intended for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic use. Handle with care and adhere to all laboratory safety protocols.