SLU-PP-332

Description

SLU-PP-332 is a novel, synthetic small molecule drug (not a peptide) that functions as a specific agonist for the Estrogen-Related Receptor Alpha (ERRα).

Unlike traditional metabolic agents that stimulate hormones or suppress appetite (like GLP-1 agonists), SLU-PP-332 acts directly on the skeletal muscle gene expression. Research indicates that it effectively “tricks” the muscle fibers into a state of endurance training. In murine models, administration of SLU-PP-332 has been observed to upregulate the expression of oxidative fibers (Type I), significantly increasing caloric expenditure and fatty acid oxidation without any increase in physical activity.

Key Research Applications

• Endurance & Mitochondria: SLU-PP-332 is the premier compound for researching mitochondrial biogenesis. Studies published in Journal of Pharmacology and Experimental Therapeutics demonstrated that treated mice could run 70% longer and 45% further than control groups, highlighting its potential to reverse mitochondrial dysfunction.

• Fat Oxidation (Spares Muscle): The compound is investigated for its ability to shift metabolism toward burning fat for fuel while preserving lean muscle mass. This “fat-selective” catabolism is a key differentiator from caloric restriction, which often results in muscle atrophy.

• Type II Diabetes & Metabolic Syndrome: By activating the ERRα pathway, SLU-PP-332 helps clear triglycerides from the blood and liver. It is heavily researched for its potential to prevent diet-induced obesity and improve insulin sensitivity in models of metabolic syndrome.

⚠️ FOR RESEARCH PURPOSES ONLY This product is intended for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic use. Handle with care and adhere to all laboratory safety protocols.